Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity

Author:

Tucker Keira1ORCID,Mageiros Leonardos2,Carstens Alno1,Bröcker Ludwig1,Archer Edward1,Smith Katrin1,Mourkas Evangelos2,Pascoe Ben2,Nel Daan3,Meric Guillaume45,Sheppard Samuel K.2,Kasprzyk-Hordern Barbara6,Botes Marelize1,Feil Edward J.2ORCID,Wolfaardt Gideon17ORCID

Affiliation:

1. Department of Microbiology, Faculty of Science, University of Stellenbosch, Matieland, Stellenbosch, South Africa

2. Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down, United Kingdom

3. Department of Statistics and Actuarial Science, Stellenbosch University, Stellenbosch, South Africa

4. Cambridge-Baker Systems Genomics Initiative, Baker Heart & Diabetes Institute, Melbourne, Victoria, Australia

5. Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia

6. Department of Chemistry, University of Bath, Bath, United Kingdom

7. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

Abstract

The results from this study are of importance as they fill a gap in the data available on environmental AMR in South Africa to date. This study was done in parallel with co-investigators focusing on the prevalence of various antimicrobials at the same sites selected in our study, verifying that the sites that are influenced by informal settlements and WWTW influent had higher concentrations of antimicrobials and antimicrobial metabolites.

Funder

Global Challenges Research Fund

National Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference63 articles.

1. O’Neill J. 2014. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev Antimicrob Resist London United Kingdom. https://wellcomecollection.org/works/rdpck35v. Accessed August 16 2022.

2. World Health Organisation. 2017. One Health. Accessed June 09 2020. https://www.who.int/news-room/q-a-detail/one-health

3. Antibiotic resistance genes identified in wastewater treatment plant systems – A review

4. Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review

5. Talking dirty - effluent and sewage irreverence in South Africa: A conservation crime perspective

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