COVID-19-Associated Pulmonary Aspergillosis Isolates Are Genomically Diverse but Similar to Each Other in Their Responses to Infection-Relevant Stresses

Author:

Mead Matthew E.1ORCID,de Castro Patrícia Alves2ORCID,Steenwyk Jacob L.1ORCID,Gangneux Jean-Pierre3ORCID,Hoenigl Martin45ORCID,Prattes Juergen4ORCID,Rautemaa-Richardson Riina67ORCID,Guegan Hélène3,Moore Caroline B.67ORCID,Lass-Flörl Cornelia8ORCID,Reizine Florian39,Valero Clara2710ORCID,Van Rhijn Norman710ORCID,Bromley Michael J.710ORCID,Rokas Antonis1ORCID,Goldman Gustavo H.2ORCID,Gago Sara710ORCID,

Affiliation:

1. Department of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, Tennessee, USA

2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

3. University of Rennes, CHU Rennes, Inserm, EHESP, IRSET (Institut de recherche en santé, environnement et travail), Rennes, France

4. Division of Infectious Diseases, Medical University of Graz, Graz, Austria

5. Biotech Med, Graz, Austria

6. Mycology Reference Centre Manchester and Department of Infectious Diseases, Manchester University, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom

7. Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

8. European Excellence Center for Medical Mycology (ECMM), Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria

9. Medical Intensive Care Unit, Rennes University Hospital, Rennes, France

10. Manchester Fungal Infection Group, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

Abstract

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) has been globally reported as a life-threatening complication in some patients with severe COVID-19. Most of these infections are caused by the environmental mold Aspergillus fumigatus , which ranks third in the fungal pathogen priority list of the WHO.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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