Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus

Author:

Steenwyk Jacob L.1ORCID,Mead Matthew E.1ORCID,de Castro Patrícia Alves2,Valero Clara2,Damasio André34,dos Santos Renato A. C.2,Labella Abigail L.1,Li Yuanning1,Knowles Sonja L.5,Raja Huzefa A.5ORCID,Oberlies Nicholas H.5,Zhou Xiaofan6,Cornely Oliver A.78910,Fuchs Frieder11ORCID,Koehler Philipp78,Goldman Gustavo H.2ORCID,Rokas Antonis1ORCID

Affiliation:

1. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil

3. Institute of Biology, University of Campinas (UNICAMP), Campinas-SP, Brazil

4. Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas-SP, Brazil

5. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA

6. Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China

7. University of Cologne, Medical Faculty and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany

8. University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany

9. ZKS Köln, Clinical Trials Centre Cologne, Cologne, Germany

10. German Center for Infection Research (DZIF), Partner Site Bonn‐Cologne, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany

11. Faculty of Medicine, Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany

Abstract

The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has already killed millions of people. COVID-19 patient outcome can be further complicated by secondary infections, such as COVID-19-associated pulmonary aspergillosis (CAPA).

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Center for Complementary and Integrative Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Howard Hughes Medical Institute

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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