Antibiotic Treatment during Gestation Enhances Susceptibility to Mycobacterium tuberculosis in Offspring-Reference-Cited by-同舟云学术

Antibiotic Treatment during Gestation Enhances Susceptibility to Mycobacterium tuberculosis in Offspring

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nyangahu Donald D.¹^ORCID,Plumlee Courtney R.¹,Brown Bryan P.¹,Feng Colin¹,Havyarimana Enock²,Cohen Sara B.¹,Urdahl Kevin B.¹,Jaspan Heather B.¹²³⁴^ORCID

Affiliation:

1. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

2. Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Republic of South Africa

3. Department of Pediatrics, University of Washington, Seattle, Washington, USA

4. Department Global Health, University of Washington, Seattle, Washington, USA

Abstract

The composition of the pioneer microbiota that colonize the infant gut are determined by the mother. Polymyxin B-induced changes in the maternal microbiota during pregnancy impact the offspring gut microbiota but not vaccine-specific CD4 T cell response. However, when infected with Mycobacterium tuberculosis , offspring born to mothers with an altered gut microbiota are susceptible to infection compared to those born to mothers not exposed to antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02491-22

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