<i>Bifidobacterium infantis</i> associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice-Reference-Cited by-同舟云学术

Bifidobacterium infantis associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice

Published:2023-12-08 Issue:49 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Nyangahu Donald D.¹^ORCID,Happel Anna-Ursula²^ORCID,Wendoh Jerome²^ORCID,Kiravu Agano²^ORCID,Wang Yuli³,Feng Colin¹,Plumlee Courtney¹^ORCID,Cohen Sara¹^ORCID,Brown Bryan P.¹^ORCID,Djukovic Danijel⁴,Ganief Tariq⁵^ORCID,Gasper Melanie¹,Raftery Daniel⁴^ORCID,Blackburn Jonathan M.⁵^ORCID,Allbritton Nancy L.³^ORCID,Gray Clive M.²⁶^ORCID,Paik Jisun⁷,Urdahl Kevin B.¹⁸^ORCID,Jaspan Heather B.¹²⁸^ORCID

Affiliation:

1. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA, USA.

2. Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa.

3. Department of Bioengineering, University of Washington, Seattle, WA, USA.

4. Northwest Metabolomics Research Center, University of Washington, Seattle, WA, USA.

5. Institute of Infectious Diseases and Molecular Medicine, Department of Integrative Biomedical Sciences, Division of Chemical and Systems Biology, University of Cape Town, Cape Town, South Africa.

6. Biomedical Research Institute, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa.

7. Department of Comparative Medicine, University of Washington, Seattle, WA, USA.

8. Department of Pediatrics, School of Medicine, University of Washington, Seattle WA, USA.

Abstract

Bacille Calmette-Guerin (BCG) vaccine can elicit good T H 1 responses in neonates. We hypothesized that the pioneer gut microbiota affects vaccine T cell responses. Infants who are HIV exposed but uninfected (iHEU) display an altered immunity to vaccination. BCG-specific immune responses were analyzed at 7 weeks of age in iHEU, and responses were categorized as high or low. Bifidobacterium longum subsp. infantis was enriched in the stools of high responders, while Bacteroides thetaiotaomicron was enriched in low responders at time of BCG vaccination. Neonatal germ-free or SPF mice orally gavaged with live B. infantis exhibited significantly higher BCG-specific T cells compared with pups gavaged with B. thetaiotaomicron. B. infantis and B. thetaiotaomicron differentially affected stool metabolome and colonic transcriptome. Human colonic epithelial cells stimulated with B. infantis induced a unique gene expression profile versus B. thetaiotaomicron . We thus identified a causal role of B. infantis in early-life antigen-specific immunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.ade1370

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