HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State-Reference-Cited by-同舟云学术

HCV Infection Increases the Expression of ACE2 Receptor, Leading to Enhanced Entry of Both HCV and SARS-CoV-2 into Hepatocytes and a Coinfection State

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Domovitz Tom¹,Ayoub Samer¹,Werbner Michal¹,Alter Joel²,Izhaki Tavor Lee²^ORCID,Yahalom-Ronen Yfat³,Tikhonov Evgeny⁴,Meirson Tomer⁵⁶,Maman Yaakov⁴,Paran Nir³,Israely Tomer³,Dessau Moshe²,Gal-Tanamy Meital¹^ORCID

Affiliation:

1. Molecular Virology Lab, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

2. The Laboratory of Structural Biology of Infectious Diseases, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

3. Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel

4. The Lab of Genomic Instability and Cancer, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

5. The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

6. Davidoff Cancer Center, Rabin Medical Center-Beilinson Hospital, Petah Tikva, Israel

Abstract

Here, we provide the first experimental evidence for the coexistence of SARS-CoV-2 infection with HCV, and the interplay between them. The study revealed a complex relationship of enhancement between the two viruses, where HCV infection increased the expression of the SARS-CoV-2 entry receptor ACE2, thus facilitating SARS-CoV-2 entry, and potentially, also HCV entry.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01150-22

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