Structural and Functional Characterization of Rv0792c from Mycobacterium tuberculosis: Identifying Small Molecule Inhibitor against HutC Protein-Reference-Cited by-同舟云学术

Structural and Functional Characterization of Rv0792c from Mycobacterium tuberculosis: Identifying Small Molecule Inhibitor against HutC Protein

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chauhan Neeraj Kumar¹,Anand Anjali¹,Sharma Arun¹,Dhiman Kanika²,Gosain Tannu Priya¹,Singh Prashant²,Singh Padam¹,Khan Eshan³,Chattopadhyay Gopinath⁴,Kumar Amit³,Sharma Deepak²,Ashish ²,Sharma Tarun Kumar¹,Singh Ramandeep¹^ORCID

Affiliation:

1. Translational Health Science and Technology Institute, Faridabad, Haryana, India

2. Institute of Microbial Technology, Council of Scientific and Industrial Research, Chandigarh, India

3. Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India

4. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India

Abstract

Prokaryotes encode a large number of GntR family transcription factors that are involved in various fundamental biological processes, including stress adaptation and pathogenesis. Here, we investigated the structural and functional role of Rv0792c, a HutC homolog from M. tuberculosis .

Funder

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01973-22

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