Breakthrough Disseminated Aspergillus ustus Infection in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Voriconazole or Caspofungin Prophylaxis

Author:

Pavie Juliette1,Lacroix Claire2,Hermoso Dea Garcia3,Robin Marie4,Ferry Christèle4,Bergeron Anne5,Feuilhade Martine2,Dromer Françoise3,Gluckman Eliane4,Molina Jean-Michel1,Ribaud Patricia4

Affiliation:

1. Service des Maladies Infectieuses et Tropicales

2. Laboratoire de Parasitologie-Mycologie

3. Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, Paris, France

4. Service d'Hématologie-Greffe de Moelle

5. Service de Pneumologie, Hôpital Saint-Louis

Abstract

ABSTRACT Aspergillus ustus is an uncommon clinical species which is poorly susceptible to antifungals. We report two cases of A. ustus infections that occurred in allogeneic stem cell transplant recipients while they were receiving either voriconazole or caspofungin. Prolonged use of these new antifungal agents may increase the risk of the emergence of resistant organisms.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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