Affiliation:
1. Department of Biochemistry, University of British Columbia, Vancouver, British Columbia, Canada
Abstract
Bragg
, P. D. (University of British Columbia, Vancouver, B. C, Canada)
and W. J. Polglase
. Electron-transport components of streptomycin-dependent
Escherichia coli
. J. Bacteriol.
86:
544–547. 1963.—When a streptomycin-dependent strain of
Escherichia coli
was grown in antibiotic-free medium, the resulting streptomycin-depleted cells were found to contain relatively large amounts of vitamin K
2
. Cytochromes
a
1
and
a
2
were absent from depleted cells, and these cells metabolized glucose with the accumulation of lactic acid. Depleted cells were normal in their content of coenzyme Q
8
, total flavine, and cytochrome
b
. Growth of depleted cells on medium containing dihydrostreptomycin restored their ability to metabolize lactic acid concomitantly with a decrease in vitamin K
2
to a normal level, and with the formation of cytochromes
a
1
and
a
2
. It is concluded that streptomycin (or dihydrostreptomycin) is required by dependent
E. coli
for maintenance of the integrity of the electron-transport system.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
21 articles.
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