Author:
Thompson H C,Eisenstein T K
Abstract
A subcellular fraction, designated PSP-3R, prepared from rough, type 3R Streptococcus pneumoniae is described, which affords excellent protection to mice against challenge with smooth organisms of the homologous serotype 3S and significant protection against heterologous challenge with serotypes 1S and 2S. Adjuvant enhances the protective capacity of the vaccine but is not necessary for immunogenicity. Protection induced by PSP-3R can be passively transferred tp normal mice with serum from actively immunized animals. The protective capacity can be completely absorbed out with rough or smooth type 3 organisms but not with rough type 1R or 2R cells. PSP-3R immune serum was tested in a passive hemagglutination assay against type 3 capsular polysaccharide-coated erythrocytes and found to have no detectable anticapsular antibody. The possible identity of the immunogen (s) in the vaccine is discussed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference25 articles.
1. Austrian R. 1971. The current status of pneumococcal disease and the potential utility of a polyvalent pneumococcal vaccine p. 359-363. In International conference on the application of vaccine against viral rickettsial and bacterial diseases of man. Pan American Sanitation Bureau Sci. publ. 226 Washington D.C.
2. A type specific protein from pneumococcus;Austrian R.;J. Exp. Med.,1949
3. Immunological relationships of cell constituents ofpneumococcus;Avery 0.;J. Exp. Med.,1923
4. Immunological relationships of cell constituents ofpneumococcus. Second paper;Avery 0.;J. Exp. Med.,1925
5. Immunological reactions of the isolated carbohydrate and protein of pneumococcus;Avery 0.;J. Exp. Med.,1925
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献