Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India-Reference-Cited by-同舟云学术

Gentamicin Susceptibility among a Sample of Multidrug-Resistant Neisseria gonorrhoeae Isolates in India

Published:2016-12 Issue:12 Volume:60 Page:7518-7521
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bala Manju¹,Singh Vikram¹²,Bhargava Aradhana¹,Kakran Monika¹,Joshi Naveen Chandra¹,Bhatnagar Ravi²

Affiliation:

1. Apex Regional STD Teaching, Training & Research Centre, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India

2. Department of Life Sciences, SunRise University, Alwar, Rajasthan, India

Abstract

ABSTRACT Antimicrobial susceptibility testing of 258 Neisseria gonorrhoeae isolates by Etest determined that 60.1% were multidrug resistant (MDR), while 5% of the strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% of MDR strains and 76.9% of strains that had decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea. However, further research regarding the clinical treatment outcomes is essential.

Funder

National AIDS Control Organisation, India

Indian Council of Medical Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01907-16

Reference29 articles.

1. The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting

2. Trends of Resistance to Antimicrobials Recommended Currently and in the Past for Management of Gonorrhea in the Apex STD Center in India and Comparison of Antimicrobial Resistance Profile Between 2002–2006 and 2007–2012