A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae

Author:

Holley Concerta L.1,Dhulipala Vijaya1,Balthazar Jacqueline T.1,Le Van Adriana2,Begum Afrin A.2,Chen Shao-Chun34ORCID,Read Timothy D.56ORCID,Matoga Mitch7,Hoffman Irving F.8,Golparian Daniel9,Unemo Magnus910,Jerse Ann E.2,Shafer William M.1611ORCID

Affiliation:

1. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

2. Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, USA

3. Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People’s Republic of China

4. National Center for Sexually Transmitted Diseases Control, Chinese Center for Disease Control and Prevention, Nanjing, People’s Republic of China

5. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

6. The Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA

7. UNC Project Malawi, Lilongwe, Malawi

8. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

9. WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

10. Institute for Global Health, University College London, London, United Kingdom

11. Laboratories of Bacterial Pathogenesis, Veterans Affairs Medical Center, Decatur, Georgia, USA

Abstract

The continued emergence of Neisseria gonorrhoeae isolates which are resistant to first-line antibiotics has reinvigorated interest in alternative therapies such as expanded use of gentamicin (Gen). We hypothesized that expanded use of Gen promotes emergence of gonococci with clinical resistance to this aminoglycoside.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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