Affiliation:
1. The R. M. Alden Research Laboratory, Santa Monica-University of California, Los Angeles Medical Center, Santa Monica, California 90404,1 and
2. University of California, Los Angeles School of Medicine, Los Angeles, California 900242
Abstract
ABSTRACT
The activities of HMR 3004 and HMR 3647 and comparator agents, especially macrolides, were determined by the agar dilution method against 262 aerobic and 120 anaerobic strains isolated from skin and soft tissue infections associated with human and animal bite wounds. HMR 3004 and HMR 3647 were active against almost all aerobic and fastidious facultative isolates (MIC at which 90% of the isolates are inhibited [MIC
90
], ≤0.5 and 1 μg/ml, respectively) and against all anaerobes [
Bacteroides tectum
,
Porphyromonas macacae
(
salivosa
),
Prevotella heparinolytica
,
Porphyromonas
sp.,
Prevotella
sp., and peptostreptococci] at ≤0.25 and ≤0.5 μg/ml, respectively, except
Fusobacterium nucleatum
(HMR 3004, MIC
90
= 16 μg/ml; HMR 3647, MIC
90
= 8 μg/ml) and other
Fusobacterium
species (MIC
90
, 1 and 2 μg/ml, respectively). In general, HMR 3004 and HMR 3647 were more active than any of the macrolides tested. Azithromycin was more active than clarithromycin against all
Pasteurella
species, including
Pasteurella multocida
subsp.
multocida
,
Eikenella corrodens
, and
Fusobacterium
species, while clarithromycin was more active than azithromycin against
Corynebacterium
species,
Weeksella zoohelcum
,
B. tectum
, and
P. heparinolytica.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
63 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Infection Related To Bites;Principles and Practice of Pediatric Infectious Diseases;2023
2. Infection Following Bites;Principles and Practice of Pediatric Infectious Diseases;2018
3. Should Antibiotics Be Prescribed to Treat Chronic Periodontitis?;Dental Clinics of North America;2015-10
4. Bites;Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases;2015
5. Infection following Bites;Principles and Practice of Pediatric Infectious Diseases;2012