Affiliation:
1. Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
Abstract
HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICs at which 50% of the strains are inhibited (MIC50s) of 0.06 to 0.125 microg/ml and MIC90s of 16.0 microg/ml against 352 anaerobes. MIC50s and MIC90s of erythromycin, azithromycin, clarithromycin, and roxithromycin were 0.5 to 2.0 microg/ml and 32.0 to >64.0 microg/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragilis-group anaerobes (other than Fusobacterium mortiferum, Fusobacterium varium, and Clostridium difficile).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference11 articles.
1. Agouridas C. Y. Benedetti A. Denis O. Le Martret and J.-F. Chantot. 1995. Ketolides: a new distinct class of macrolide antibacterials-synthesis and structural characteristics of RU 004 abstr. F157 p. 140. In Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.
2. Antianaerobic activity of the ketolide RU 64004 compared to activities of four macrolides, five ~-lactams, clindamycin, and metronidazole;Ednie L. M.;Antimicrob. Agents Chemother.,1997
3. Gram-negative anaerobic bacilli: their role in infection and patterns of susceptibility to antimicrobial agents. II. Little-known Fusobacterium species and miscellaneous genera;George W. L.;Rev. Infect. Dis.,1981
4. In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004;Jamjian C.;Antimicrob. Agents Chemother.,1997
5. Antimicrobial activity of RU66647, a new ketolide;Jones R. N.;Diagn. Microbiol. Infect. Dis.,1997
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