Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines-Reference-Cited by-同舟云学术

Mice Lacking γδ T Cells Exhibit Impaired Clearance of Pseudomonas aeruginosa Lung Infection and Excessive Production of Inflammatory Cytokines

Published:2020-05-20 Issue:6 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Omar Toka¹,Ziltener Pascal¹,Chamberlain Erin¹,Cheng Zhenyu¹^ORCID,Johnston Brent¹²³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

2. Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada

3. Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic and life-threatening infections in immunocompromised patients. A better understanding of the role that innate immunity plays in the control of P. aeruginosa infection is crucial for therapeutic development. Specifically, the role of unconventional immune cells like γδ T cells in the clearance of P. aeruginosa lung infection is not yet well characterized.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00171-20

Reference45 articles.

1. Reference deleted.

2. The Pseudomonas aeruginosa opportunistic pathogen and human infections

3. Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway