dd -Carboxypeptidase-Transpeptidase and Killing Site of β-Lactam Antibiotics in Streptomyces Strains R39, R61, and K11

Author:

Dusart Jean123,Marquet Alberto123,Ghuysen Jean-Marie123,Frère Jean-Marie123,Moreno Ramon123,Leyh-Bouille Melina123,Johnson Kenneth123,Lucchi Chantal123,Perkins Harold R.123,Nieto Manuel123

Affiliation:

1. Service de Microbiologie, Faculté de Médecine, Institut de Botanique, Université de Liège, Sart-Tilman, 4000 Liège, Belgium

2. National Institute for Medical Research, Mill Hill, London, England

3. Centro de Investigaciones Biologicas, Instituto de Biologia Celular, Madrid, Spain

Abstract

Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd -carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of β-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, β-lactamase activity was not involved in susceptibility to β-lactam antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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