dd -Carboxypeptidase-Transpeptidase and Killing Site of β-Lactam Antibiotics in Streptomyces Strains R39, R61, and K11-Reference-Cited by-同舟云学术

dd -Carboxypeptidase-Transpeptidase and Killing Site of β-Lactam Antibiotics in Streptomyces Strains R39, R61, and K11

Published:1973-02 Issue:2 Volume:3 Page:181-187
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dusart Jean¹²³,Marquet Alberto¹²³,Ghuysen Jean-Marie¹²³,Frère Jean-Marie¹²³,Moreno Ramon¹²³,Leyh-Bouille Melina¹²³,Johnson Kenneth¹²³,Lucchi Chantal¹²³,Perkins Harold R.¹²³,Nieto Manuel¹²³

Affiliation:

1. Service de Microbiologie, Faculté de Médecine, Institut de Botanique, Université de Liège, Sart-Tilman, 4000 Liège, Belgium

2. National Institute for Medical Research, Mill Hill, London, England

3. Centro de Investigaciones Biologicas, Instituto de Biologia Celular, Madrid, Spain

Abstract

Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd -carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of β-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, β-lactamase activity was not involved in susceptibility to β-lactam antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.3.2.181

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