Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pantel Lucile¹,Juarez Paulo²^ORCID,Serri Marine¹,Boucinha Lilia³,Lessoud Emilie³,Lanois Anne⁴,Givaudan Alain⁴^ORCID,Racine Emilie¹,Gualtieri Maxime¹^ORCID

Affiliation:

1. Nosopharm, Nîmes, France

2. Research and Development Department, Smaltis SAS, Besançon, France

3. Evotec ID (Lyon), Lyon, France

4. DGIMI, INRAE, Université de Montpellier, Montpellier, France

Abstract

NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the colistin (CST)-resistant strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00139-21

Reference38 articles.

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