SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures

Author:

Barzin Amir1,Schmitz John L.23,Rosin Samuel4,Sirpal Rameet5,Almond Martha6,Robinette Carole6,Wells Samantha1,Hudgens Michael4,Olshan Andrew7,Deen Stephanie8,Krejci Patrick5,Quackenbush Eugenia9,Chronowski Kevin9,Cornaby Caleb2,Goins Janette10,Butler Linda11,Aucoin Julia11,Boyer Kim11,Faulk Janet11,Alston-Johnson Devena12,Page Cristen1,Zhou Yijun313,Fiscus Lynne5,Damania Blossom313,Dittmer Dirk P.313ORCID,Peden David B.61014

Affiliation:

1. The University of North Carolina at Chapel Hill School of Medicine, Department of Family Medicine, Chapel Hill, North Carolina, USA

2. The University of North Carolina at Chapel Hill School of Medicine, Department of Pathology and Laboratory Medicine and UNC Hospitals McLendon Clinical Laboratories, Chapel Hill, North Carolina, USA

3. The University of North Carolina at Chapel Hill School of Medicine, Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA

4. The University of North Carolina at Chapel Hill Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, North Carolina, USA

5. UNC Physicians Network, Chapel Hill, North Carolina, USA

6. The University of North Carolina at Chapel Hill School of Medicine, Center for Environmental Medicine, Asthma and Lung Biology, Chapel Hill, North Carolina, USA

7. The University of North Carolina at Chapel Hill Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA

8. UNC Health Information Services Division, Chapel Hill, North Carolina, USA

9. The University of North Carolina at Chapel Hill School of Medicine, Department of Emergency Medicine, Chapel Hill, North Carolina, USA

10. The University of North Carolina at Chapel Hill, North Carolina Translational and Clinical Sciences Institute, Chapel Hill, North Carolina, USA

11. UNC REX Healthcare, Raleigh, North Carolina, USA

12. UNC Health Nash General Hospital, Rocky Mount, North Carolina, USA

13. The University of North Carolina at Chapel Hill School of Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA

14. The University of North Carolina at Chapel Hill School of Medicine, Department of Pediatrics, Chapel Hill, North Carolina, USA

Abstract

This study suggests limited but accelerating asymptomatic spread of SARS-CoV-2. Asymptomatic infections, like symptomatic infections, disproportionately affected vulnerable communities in this population, and seroprevalence was higher in African American participants than in White participants. The low, overall prevalence may reflect the success of shelter-in-place mandates at the time this study was performed and of maintaining effective physical distancing practices among suburban populations. Under these public health measures and aggressive case finding, outbreak clusters did not spread into the general population.

Funder

University Cancer Research Fund

HHS | National Institutes of Health

National Science Foundation

U.S. Environmental Protection Agency

UNC | UNC-CH | School of Medicine, University of North Carolina at Chapel Hill

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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