Key Residue in the Precursor Region of M Protein Contributes to the Neurovirulence and Neuroinvasiveness of the African Lineage of Zika Virus

Author:

He Meng-Jiao1,Wang Hong-Jiang2,Yan Xiu-Li13,Lou Ya-Nan1,Song Guang-Yuan13,Li Rui-Ting1,Zhu Zhu14,Zhang Rong-Rong1,Qin Cheng-Feng1ORCID,Li Xiao-Feng1ORCID

Affiliation:

1. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China

2. Department of Research, The Chinese People’s Liberation Army Strategic Support Force Medical Center, Beijing, China

3. School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China

4. School of Medicine, Tsinghua University, Beijing, China

Abstract

The suspected link of Zika virus (ZIKV) to birth defects led the World Health Organization to declare ZIKV a Public Health Emergency of International Concern. ZIKV has been identified to have two dominant phylogenetic lineages, African and Asian.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

NSFC | National Science Fund for Distinguished Young Scholars

Foundation for Innovative Research Groups of the National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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