NOD2/c-Jun NH 2 -Terminal Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy-Reference-Cited by-同舟云学术

NOD2/c-Jun NH 2 -Terminal Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy

Published:2020-09-23 Issue:20 Volume:202 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Luo Haixia¹²^ORCID,Wu Xixi¹²,Xu Zhaokun¹²,Hao Xiujing¹²,Wang Yongyu¹²,Li Min¹²

Affiliation:

1. Life Science School, Ningxia University, Yinchuan, Ningxia Hui Autonomous Region, China

2. Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan, Ningxia Hui Autonomous Region, China

Abstract

M. ovipneumoniae , which lacks a cell wall, causes infectious pleuropneumonia in goats and sheep. In the present study, we focused on the interaction between NOD and M. ovipneumoniae , as well as its association with autophagy. We showed for the first time that NOD2 was activated by M. ovipneumoniae even when peptidoglycans were not present. We also observed that both NOD2 and JNK pathway activation promoted M. ovipneumoniae -induced autophagy.

Funder

key R & D projects of Ningxia Hui Autonomous Region

Major innovation projects for building First-class universitites China's Western region

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00689-19

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