Comparative Activities of AM-715 and Pipemidic and Nalidixic Acids Against Experimentally Induced Systemic and Urinary Tract Infections

Author:

Hirai Keiji1,Ito Akira1,Abe Yashuo2,Suzue Seigo2,Irikura Tsutomu2,Inoue Matsuhisa1,Mitsuhashi Susumu1

Affiliation:

1. Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan

2. Central Research Laboratory, Kyorin Pharmaceutical Company, Ltd., Tochigi, Japan

Abstract

Dose for dose, AM-715 was at least five times as active as pipemidic acid and nalidixic acid against systemic and urinary bladder-kidney infections in mice.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference4 articles.

1. In vitro antibacterial activity of AM-715, a new nalidixic acid analog;Ito A.;Antimicrob. Agents Chemother.,1980

2. A simplified method of evaluation dose-effect experiments;Lithfield J. T.;J. Pharmacol.,1948

3. Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa; in vitro properties;Simizu M.;Antimicrob. Agents Chemother.,1975

4. Pipemidic acid: its activities against various experimental infections;Simizu M.;Antimicrob. Agents Chemother.,1976

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