Affiliation:
1. Research and Development Division, Dainippon Pharmaceutical Co., Ltd., Suita, Osaka, Japan
Abstract
Pipemidic acid, a structural relative of piromidic and nalidixic acids, exhibited substantial therapeutic activity when it was administered orally to mice bearing either widely disseminated or relatively localized infections with
Staphylococcus aureus
and a variety of gram-negative bacilli. The activity of pipemidic acid was always greater than that of piromidic and nalidixic acids; in infections with
Pseudomonas aeruginosa
and in bacilli resistant to the latter two drugs, pipemidic acid exhibited significant activity. In limited comparative studies, the activities of pipemidic acid were generally superior to the activities of cephalexin, ampicillin, and carbenicillin. Gentamicin, administered subcutaneously, was more active than pipemidic acid, given either orally or subcutaneously, against both systemic and localized infections with
P. aeruginosa
. The therapeutic accomplishments of pipemidic acid were attained with well-tolerated doses.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference7 articles.
1. 1,8-Naphthyridine derivatives. A new class of chemotherapeutic agents;Lesher G. Y.;J. Med. Pharm. Chem.,1962
2. A simplified method of evaluating dose-effect experiments;Litchfleld J. T.;J. Pharmacol. Exp. Ther.,1949
3. Pyrido[2,3- dipyrimidine antibacterial agents. 3. 8-Alkyl- and 8- viny1-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]- pyrimidine-6-carboxylic acids and their derivatives;Matsumoto J.;J. Med. Chem.,1975
4. Estimation of the ED5o and its error by means of logarithmic-probit graph paper;Miller L. C.;Proc. Soc. Exp. Biol. Med.,1944
5. Shimizu M. S. Nakamura and Y. Takase. 1971. Piromidic acid a new antibacterial agent: antibacterial properties p. 117-122. Antimicrob. Agents Chemother. 1970.
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