Neural-Cell-Intrinsic NF-κB Signaling Enhances Reovirus Virulence-Reference-Cited by-同舟云学术

Neural-Cell-Intrinsic NF-κB Signaling Enhances Reovirus Virulence

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Taylor Gwen M.¹²,Pruijssers Andrea J.³⁴,Brigleb Pamela H.²⁵,Fiske Kay L.¹²,Shang Pengcheng¹²,Urbanek Kelly¹²,Brown Judy J.⁴⁶,Rajasundaram Dhivyaa¹,Dermody Terence S.¹²⁵^ORCID

Affiliation:

1. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

2. Institute of Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA

3. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

4. Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

6. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Viral encephalitis contributes to illness and death in children and adults worldwide and has limited treatment options. Identifying common host factors upregulated by neurotropic viruses can enhance an understanding of virus-induced neuropathogenesis and aid in development of therapeutics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01442-22

Reference47 articles.

1. Hostile takeovers: viral appropriation of the NF-kB pathway

2. Cellular Specificity of NF-κB Function in the Nervous System

3. IκB Kinase Subunits α and γ Are Required for Activation of NF-κB and Induction of Apoptosis by Mammalian Reovirus

4. Reovirus-Induced Apoptosis Requires Activation of Transcription Factor NF-κB

5. Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus