Prominent Binding of Human and Equine Fibrinogen to Streptococcus equi subsp. zooepidemicus Is Mediated by Specific SzM Types and Is a Distinct Phenotype of Zoonotic Isolates-Reference-Cited by-同舟云学术

Prominent Binding of Human and Equine Fibrinogen to Streptococcus equi subsp. zooepidemicus Is Mediated by Specific SzM Types and Is a Distinct Phenotype of Zoonotic Isolates

Published:2019-12-17 Issue:1 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bergmann René¹,Jentsch Maria-Christin¹,Uhlig Albrecht²,Müller Uwe³,van der Linden Mark⁴,Rasmussen Magnus⁵,Waller Andrew⁶,von Köckritz-Blickwede Maren⁷⁸,Baums Christoph Georg¹^ORCID

Affiliation:

1. Institute of Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany

2. Department for Horses, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany

3. Institute of Immunology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany

4. German National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany

5. Division of Infection Medicine, Lund University, Lund, Sweden

6. Animal Health Trust, New Market, Suffolk, United Kingdom

7. Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany

8. Germany and Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, Hannover, Germany

Abstract

Streptococcus equi subsp. zooepidemicus is an important pathogen in horses that causes severe diseases such as pneumonia and abortion. Furthermore, it is a zoonotic agent, and contact with horses is a known risk factor. In this study, we investigated the working hypothesis that the zoonotic potential varies among S. equi subsp. zooepidemicus strains in association with differences in M-like protein-mediated binding of host plasma proteins.

Funder

Universität Leipzig

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00559-19

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3. Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases