Mice Lacking Alpha/Beta and Gamma Interferon Receptors Are Susceptible to Junin Virus Infection-Reference-Cited by-同舟云学术

Mice Lacking Alpha/Beta and Gamma Interferon Receptors Are Susceptible to Junin Virus Infection

Published:2010-12-15 Issue:24 Volume:84 Page:13063-13067
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kolokoltsova Olga A.¹,Yun Nadezda E.¹,Poussard Allison L.¹,Smith Jennifer K.¹,Smith Jeanon N.¹,Salazar Milagros¹,Walker Aida¹,Tseng Chien-Te K.²,Aronson Judith F.¹²,Paessler Slobodan¹

Affiliation:

1. Galveston National Laboratory, Department of Pathology

2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas

Abstract

ABSTRACT Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01389-10

Reference25 articles.

1. Berria, M. I., and E. F. Lascano. 1985. Astrocyte differentiation induced by Junin virus in rat brain cell cultures. Acta Neuropathol.66:233-238.

2. Berria, M. I., and E. F. Lascano. 1981. Comparative study of Junin and herpes simplex viruses in mouse brain monolayer cultures. Medicina (B. Aires)41:459-466.

3. Caccuri, R. L., R. F. Iacono, M. C. Weissenbacher, M. M. Avila, and M. I. Berria. 2003. Long-lasting astrocyte reaction to persistent Junin virus infection of rat cortical neurons. J. Neural Transm.110:847-857.

4. Cossio, P., R. Laguens, R. Arana, A. Segal, and J. Maiztegui. 1975. Ultrastructural and immunohistochemical study of the human kidney in Argentine haemorrhagic fever. Virchows Arch. A Pathol. Anat. Histol.368:1-9.

5. Elsner, B., E. Schwarz, O. G. Mando, J. Maiztegui, and A. Vilches. 1973. Pathology of 12 fatal cases of Argentine hemorrhagic fever. Am. J. Trop. Med. Hyg.22:229-236.

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats;mSphere;2024-09-11

2. Temporal changes in pathology and viral RNA distribution in guinea pigs following separate infection with two New World Arenaviruses;PLOS Neglected Tropical Diseases;2023-09-08

3. The knowns and unknowns of cardiac autoimmunity in viral myocarditis;Reviews in Medical Virology;2023-09-02

4. A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein;PLOS Pathogens;2023-01-05

5. Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling;Frontiers in Genetics;2022-09-14