Kinetics of Bacterial Inactivation by Peroxynitric Acid in the Presence of Organic Contaminants

Author:

Yokoyama Takashi1ORCID,Miyazaki Shinya1,Akagi Hiroko1,Ikawa Satoshi2,Kitano Katsuhisa1

Affiliation:

1. Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan

2. Osaka Research Institute of Industrial Science and Technology, Izumi, Osaka, Japan

Abstract

A good disinfectant for the human body should have various properties, such as strong bactericidal activity, harmlessness to living tissues, and resistance against biological fluids (or other organic contaminants). Peroxynitric acid (PNA) showed a bactericidal effect that was several tens up to several hundred times higher per unit of molarity than that of sodium hypochlorite and peracetic acid, which are used as general disinfectants for medical equipment. Moreover, the high resistance of PNA to organic load was confirmed, indicating that PNA will inactivate bacteria effectively even on contaminated surfaces, such as used medical devices or the human body surface. Therefore, we propose that PNA can be used as a strong disinfectant for the human body.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference61 articles.

1. Best practices for disinfection of noncritical environmental surfaces and equipment in health care facilities: A bundle approach

2. Fauerbach LL, Janelle JW. 2001. Practical applications in infection control, p 935–944. In Block SS (ed), Disinfection, sterilization, and preservation, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.

3. Rutala WA Weber DJ Healthcare Infection Control Practices Advisory Committee. 2008. Guideline for disinfection and sterilization in healthcare facilities. Centers for Disease Control and Prevention. https://www.cdc.gov/infectioncontrol/pdf/guidelines/disinfection-guidelines-H.pdf. Accessed September 2020.

4. National Research Council (US) Committee on Acute Exposure Guideline Levels. 2010. Peracetic acid, p 327–367. In Acute exposure guideline levels for selected airborne chemicals. National Academies Press, Washington, DC.

5. IARC. 2006. Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. Monographs on the evaluation of carcinogenic risks to humans, vol 88. IARC, Lyons, France.

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