Telithromycin Susceptibility and Genomic Diversity of Macrolide-Resistant Serotype III Group B Streptococci Isolated in Perinatal Infections-Reference-Cited by-同舟云学术

Telithromycin Susceptibility and Genomic Diversity of Macrolide-Resistant Serotype III Group B Streptococci Isolated in Perinatal Infections

Published:2004-02 Issue:2 Volume:48 Page:677-680
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bingen Edouard¹,Doit Catherine¹,Bidet Philippe¹,Brahimi Naima¹,Deforche Dominique¹

Affiliation:

1. Laboratoire d'Études de Génétique Bactérienne dans les Infections de l'Enfant (EA3105), Service de Microbiologie, Hôpital Robert Debré (AP-HP), Université Denis Diderot-Paris 7, 75019 Paris, France

Abstract

ABSTRACT We studied the telithromycin, erythromycin, azithromycin, and clindamycin susceptibilities of serotype III macrolide-resistant group B streptococci, together with genetic mechanisms of resistance and genomic diversity. ermB , ermA , and mefA were found in, respectively, 57, 32, and 9% of isolates. The telithromycin MIC at which 90% of isolates were inhibited was 0.5 μg/ml. Macrolide resistance was associated with dissemination of resistance determinants among isolates of different genetic backgrounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.2.677-680.2004

Reference28 articles.

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