Erythromycin and Clindamycin Resistance and Telithromycin Susceptibility in Streptococcus agalactiae

Author:

Betriu C.1,Culebras E.1,Gómez M.1,Rodríguez-Avial I.1,Sánchez B. A.1,Ágreda M. C.1,Picazo J. J.1

Affiliation:

1. Department of Clinical Microbiology, Hospital Clínico San Carlos, 28040 Madrid, Spain

Abstract

ABSTRACT The rates of resistance to erythromycin and clindamycin among Streptococcus agalactiae strains isolated in our hospital increased from 4.2 and 0.8% in 1993 to 17.4 and 12.1%, respectively, in 2001. Erythromycin resistance was mainly due to the presence of an Erm(B) methylase, while the M phenotype was detected in 3.8% of the strains. Telithromycin was very active against erythromycin-resistant strains, irrespective of their mechanisms of macrolide resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference21 articles.

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2. Barry, A. L., P. C. Fuchs, and S. D. Brown. 2001. Relative potency of telithromycin, azithromycin and erythromycin against recent clinical isolates of gram-positive cocci. Eur. J. Clin. Microbiol. Infect. Dis.20:494-497.

3. Antibiotic resistance and penicillin tolerance in clinical isolates of group B streptococci

4. Centers for Disease Control and Prevention. 1996. Prevention of perinatal group B streptococcal disease: a public health perspective. Morb. Mortal. Wkly. Rep.45:1-24.

5. Macrolide and Tetracycline Resistance and Molecular Relationships of Clinical Strains of Streptococcus agalactiae

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