Affiliation:
1. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Abstract
Schistosoma japonicum-infected mice were treated with antibodies to interleukin-5 (IL-5) or gamma interferon (IFN-gamma) from week 3 or 4 to week 10 of infection. Neither antibody affected egg production by the parasite, and neither had a consistent effect on the secretion of IFN-gamma or IL-5 cell-related cytokines by spleen cells from infected mice. Mice treated with antibody to murine IL-5 had only rare eosinophils in hepatic circumoval granulomas. Granulomas around single eggs were reduced in volume by a third, but hepatic fibrosis was unaffected. Treatment with antibody to murine IFN-gamma also reduced the size of granulomas and also did not affect hepatic fibrosis, which was measured as hydroxyproline. Our results, taken together with the studies of others, indicate that a complex interaction of cytokines affects granuloma size and that the size and fibrosis of granulomas are to some extent regulated independently.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
36 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献