Analysis of egg granuloma formation in Schistosoma japonicum-infected mice treated with antibodies to interleukin-5 and gamma interferon

Author:

Cheever A W1,Xu Y H1,Sher A1,Macedonia J G1

Affiliation:

1. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

Abstract

Schistosoma japonicum-infected mice were treated with antibodies to interleukin-5 (IL-5) or gamma interferon (IFN-gamma) from week 3 or 4 to week 10 of infection. Neither antibody affected egg production by the parasite, and neither had a consistent effect on the secretion of IFN-gamma or IL-5 cell-related cytokines by spleen cells from infected mice. Mice treated with antibody to murine IL-5 had only rare eosinophils in hepatic circumoval granulomas. Granulomas around single eggs were reduced in volume by a third, but hepatic fibrosis was unaffected. Treatment with antibody to murine IFN-gamma also reduced the size of granulomas and also did not affect hepatic fibrosis, which was measured as hydroxyproline. Our results, taken together with the studies of others, indicate that a complex interaction of cytokines affects granuloma size and that the size and fibrosis of granulomas are to some extent regulated independently.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference22 articles.

1. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline;Bergman I.;Anal. Chem.,1963

2. Regulation of collagen gene expression;Bornstein P.;Prog. Nucleic Acid Res. Mol. Biol.,1989

3. Interferon-y activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A,B, tumor necrosis factor and complement component C3 in mouse macrophages;Celada A.;Eur. J. Immunol.,1989

4. Relative resistance of the eggs of human schistosomes to digestion in potassium hydroxide;Cheever A. W.;Bull. W. H. O.,1970

5. The intensity of experimental schistosome infections modulates hepatic pathology;Cheever A. W.;Am. J. Trop. Med. Hyg.,1986

Cited by 36 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Schistosoma and schistosomiasis;Molecular Medical Microbiology;2024

2. Schistosomiasis;Helminth Infections and their Impact on Global Public Health;2022

3. Eosinophils and helminth infection: protective or pathogenic?;Seminars in Immunopathology;2021-06

4. Granuloma formation and tissue pathology in Schistosoma japonicum versus Schistosoma mansoni infections;Parasite Immunology;2020-08-18

5. Eosinophils and Macrophages within the Th2-Induced Granuloma: Balancing Killing and Healing in a Tight Space;Infection and Immunity;2019-10

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3