Segmental Variation in a Duplicated msp2 Pseudogene Generates Anaplasma marginale Antigenic Variants-Reference-Cited by-同舟云学术

Segmental Variation in a Duplicated msp2 Pseudogene Generates Anaplasma marginale Antigenic Variants

Published:2019-02 Issue:2 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Graça Telmo¹,Ku Pei-Shin¹²,Silva Marta G.²,Turse Joshua E.²,Hammac G. Kenitra¹²,Brown Wendy C.²,Palmer Guy H.¹,Brayton Kelly A.¹²

Affiliation:

1. Paul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA

2. Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA

Abstract

Anaplasma marginale is a prototypical highly antigenically variant bacterial pathogen dependent on the sequential generation of major surface protein 2 (Msp2) outer membrane variants to establish persistent infection. Msp2 is encoded by a single expression site, and diversity is achieved by gene conversion of chromosomally encoded msp2 pseudogenes.

Funder

United States Department of Agriculture

US-Israel Binational Agricultural Research and Development Fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00727-18

Reference19 articles.

1. Phase and Antigenic Variation in Bacteria