Abstract
Abstract
Pseudogenes are defined as “non-functional” copies of corresponding parent genes. The cognition of pseudogenes continues to be refreshed through accumulating and updating research findings. Previous studies have predominantly focused on mammals, but pseudogenes have received relatively less attention in the field of microbiology. Given the increasing recognition on the importance of pseudogenes, in this review, we focus on several aspects of microorganism pseudogenes, including their classification and characteristics, their generation and fate, their identification, their abundance and distribution, their impact on virulence, their ability to recombine with functional genes, the extent to which some pseudogenes are transcribed and translated, and the relationship between pseudogenes and viruses. By summarizing and organizing the latest research progress, this review will provide a comprehensive perspective and improved understanding on pseudogenes in microorganisms.
Key points
• Concept, classification and characteristics, identification and databases, content, and distribution of microbial pseudogenes are presented.
• How pseudogenization contribute to pathogen virulence is highlighted.
• Pseudogenes with potential functions in microorganisms are discussed.
Funder
Grants from Zhong Ze Zhen Xing Program of Jiangsu Province
High End Talent Program for International Collaboration
A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献