Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin-Reference-Cited by-同舟云学术

Macrophage-Derived Cell Lines Do Not Express Proinflammatory Cytokines after Exposure to Bacillus anthracis Lethal Toxin

Published:2001-02 Issue:2 Volume:69 Page:1175-1177
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Erwin James L.¹²,DaSilva Luis M.³,Bavari Sina³,Little Stephen F.⁴,Friedlander Arthur M.¹,Chanh Tran C.¹²

Affiliation:

1. Headquarters,1

2. Division of Virology,2

3. Division of Toxinology,3 and

4. Division of Bacteriology,4 United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702–5011

Abstract

ABSTRACT We present evidence that Bacillus anthracis lethal toxin (LT) suppresses rather than induces proinflammatory cytokine production in macrophages. Suppression is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.2.1175-1177.2001

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5. Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFN gamma-induced release of NO and TNFalpha;Pellizzari R.;FEBS Lett.,1999

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