Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor-Reference-Cited by-同舟云学术

Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

Published:1998-05 Issue:5364 Volume:280 Page:734-737
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Duesbery Nicholas S.¹²³⁴⁵,Webb Craig P.¹²³⁴⁵,Leppla Stephen H.¹²³⁴⁵,Gordon Valery M.¹²³⁴⁵,Klimpel Kurt R.¹²³⁴⁵,Copeland Terry D.¹²³⁴⁵,Ahn Natalie G.¹²³⁴⁵,Oskarsson Marianne K.¹²³⁴⁵,Fukasawa Kenji¹²³⁴⁵,Paull Ken D.¹²³⁴⁵,Vande Woude George F.¹²³⁴⁵

Affiliation:

1. N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.

2. S. H. Leppla, V. M. Gordon, K. R. Klimpel, National Institute of Dental Research–National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

3. N. G. Ahn, Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Campus Box 215, Boulder, CO 80309, USA.

4. K. Fukasawa, Department of Cell Biology, University of Cincinnati, College of Medicine, P.O. Box 670521, Cincinnati, OH 45267, USA.

5. K. D. Paull, Division of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be a metalloprotease, but no physiological substrates have been identified. Here it is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 (MAPKK1 and MAPKK2) and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway. The identification of a cleavage site for LF may facilitate the development of LF inhibitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. S. H. Leppla in Handbook of Natural Toxins J. Moss B. Iglewski M. Vaughan A. T. Tu Eds. (Dekker New York 1995) vol. 8 pp. 543–572.

2. V. M. Gordon, S. H. Leppla, E. L. Hewlett, Infect. Immun. 56, 1066 (1988); Milne J. C., Furlong D., Hanna P. C., Wall J. S., Collier R. J., J. Biol. Chem. 269, 20607 (1994).

3. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

4. Pezard C., Berche P., Mock M., Infect. Immun.59, 3472 (1991).

5. Ezzell J. W., Ivins B. E., Leppla S. H., ibid45, 761 (1984).

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