HAMLET, a Protein Complex from Human Milk, Has Bactericidal Activity and Enhances the Activity of Antibiotics against Pathogenic Streptococci-Reference-Cited by-同舟云学术

HAMLET, a Protein Complex from Human Milk, Has Bactericidal Activity and Enhances the Activity of Antibiotics against Pathogenic Streptococci

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alamiri Feiruz¹,Riesbeck Kristian²,Hakansson Anders P.¹^ORCID

Affiliation:

1. Division of Experimental Infection Medicine, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmo, Sweden

2. Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmo, Sweden

Abstract

HAMLET ( h uman a lpha-lactalbumin m ade le thal to t umor cells) is a protein-lipid complex derived from human milk that was first described for its tumoricidal activity. Later studies showed that HAMLET also has direct bactericidal activity against select species of bacteria, with highest activity against Streptococcus pneumoniae .

Funder

Anna och Edvin Berger Foundation

Vetenskapsrådet

Kungliga Fysiografiska Sällskapet i Lund

Alfred Österlunds Stiftelse

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01193-19

Reference51 articles.

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4. A Novel Initiation Mechanism of Death in Streptococcus pneumoniae Induced by the Human Milk Protein-Lipid Complex HAMLET and Activated during Physiological Death

5. A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis

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