Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity-Reference-Cited by-同舟云学术

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pestrak Matthew J.¹^ORCID,Baker Perrin²,Dellos-Nolan Sheri¹,Hill Preston J.¹,Passos da Silva Daniel³,Silver Holly³,Lacdao Ira²,Raju Deepa²,Parsek Matthew R.³,Wozniak Daniel J.¹⁴,Howell P. Lynne²⁵

Affiliation:

1. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA

2. Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

3. Department of Microbiology, University of Washington, Seattle, Washington, USA

4. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

5. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

Abstract

Pseudomonas aeruginosa is an opportunistic, nosocomial bacterial pathogen that forms persistent infections due to the formation of protective communities, known as biofilms. Once the biofilm is formed, the bacteria embedded within it are recalcitrant to antimicrobial treatment and host immune defenses.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | CIHR | CIHR Skin Research Training Centre

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00234-19

Reference47 articles.

1. Multistate Point-Prevalence Survey of Health Care–Associated Infections

2. Bacterial Biofilms: A Common Cause of Persistent Infections