Host-Cell Lysosomal Response to Two Strains of Herpes Simplex Virus-Reference-Cited by-同舟云学术

Host-Cell Lysosomal Response to Two Strains of Herpes Simplex Virus

Published:1970-02 Issue:2 Volume:5 Page:226-229
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Fine D. L.¹,Lake R. S.¹,Ludwig E. H.¹

Affiliation:

1. Department of Microbiology, The Pennsylvania State University, University Park, Pennsylvania 16802

Abstract

A correlation has been made between the host lysosomal responses to and release of infectious virus from HEp-2 cells infected with two strains of herpes simplex virus (HSV). Supravital staining with acridine orange was used for morphological studies of macroplaque and microplaque HSV-infected cells. With the progression of infection, cells infected with either microplaque HSV or macroplaque HSV were observed to undergo different lysosomal and cytopathic changes, which could be correlated with increased accumulation of acid phosphatase and infectious virus in the extracellular fluid.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.5.2.226-229.1970

Reference11 articles.

1. Allison A. C. 1967. Lysosomes in virus-infected cells p. 29-62. In M. Pollard (ed.) Perspectives in virology vol. 5. Academic Press Inc. New York.

2. Lysosomal changes in lytic and nonlytic infections with the Simian vacuolating virus (SV 40);Allison A. C.;J. Nat. Cancer Inst.,1967

3. Activation of Iysosomal enzymes in virus-infected cells and its possible relationship to cytopathic effects;Allison A. C.;J. Exp. Med.,1963

4. Hydrolytic enzymes in KB cells infected with poliovirus and herpes simplex virus;Flanagan J. F.;J. Bacteriol.,1966

5. Further studies of variants of herpes simplex virus that produce syncytia or pocklike lesions in cell cultures;Hoggan M. D.;Amer. J. Hyg.,1961

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