Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection-Reference-Cited by-同舟云学术

Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

Published:2005-01 Issue:1 Volume:73 Page:617-621
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kelly Michelle N.¹,Kolls Jay K.²,Happel Kyle³,Schwartzman Joseph D.⁴,Schwarzenberger Paul⁵,Combe Crescent¹,Moretto Magali¹,Khan Imtiaz A.¹

Affiliation:

1. Department of Microbiology, Immunology and Parasitology

2. Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania

3. Department of Pulmonary Medicine

4. Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire

5. Division of Gene Therapy, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Abstract

ABSTRACT We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii . IL-17R −/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.1.617-621.2005

Reference18 articles.

1. Alexander, J., T. M. Scharton-Kersten, G. Yap, C. W. Roberts, F. Y. Liew, and A. Sher. 1997. Mechanisms of innate resistance to Toxoplasma gondii infection. Philos. Trans. R. Soc. London B352:1355-1359.

2. Bliss, S. K., B. A. Butcher, and E. Y. Denkers. 2000. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J. Immunol.165:4515-4521.

3. Neutrophil Depletion during Toxoplasma gondii Infection Leads to Impaired Immunity and Lethal Systemic Pathology

4. CD8 + -T-Cell Immunity against Toxoplasma gondii Can Be Induced but Not Maintained in Mice Lacking Conventional CD4 + T Cells

5. Del Rio, L., S. Bennouna, J. Salinas, and E. Y. Denkers. 2001. CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. J. Immunol.167:6503-6509.

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