Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop-Reference-Cited by-同舟云学术

Atypical Ebola Virus Disease in a Nonhuman Primate following Monoclonal Antibody Treatment Is Associated with Glycoprotein Mutations within the Fusion Loop

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Banadyga Logan¹^ORCID,Zhu Wenjun¹,Kailasan Shweta²,Howell Katie A.²,Franaszek Krzysztof²,He Shihua¹,Siragam Vinayakumar¹,Cheng Keding³,Yan Feihu¹⁴,Moffat Estella⁵,Cao Wenguang¹,Leung Anders¹,Embury-Hyatt Carissa⁵,Aman M. Javad²,Qiu Xiangguo¹

Affiliation:

1. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

2. Integrated BioTherapeutics, Inc., Rockville, Maryland, USA

3. Science and Technology Core, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada

4. Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China

5. Canadian Food Inspection Agency, National Centre for Foreign and Animal Disease, Winnipeg, Canada

Abstract

Ebola virus remains a global threat to public health and biosecurity, yet we still know relatively little about its pathogenesis and the complications that arise following recovery. With nearly 20,000 survivors from the 2013–2016 West African outbreak, as well as over 1,000 survivors of the recent outbreak in the DRC, we must consider the consequences of virus persistence and recrudescent disease, even if they are rare.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

DOD | Defense Threat Reduction Agency

Public Health Agency of Canada

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01438-20

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