Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study-Reference-Cited by-同舟云学术

Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study

Published:2019-02-26 Issue:3 Volume:6 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Liu William J¹,Sesay Foday R²,Coursier Antoine³,Knust Barbara⁴,Marrinan Jaclyn E³,Whitmer Shannon⁴,McDonald Suzanna L R³,Gaillard Philippe³,Liu Yang¹,Su Qiudong¹,Zhang Yong¹,Crozier Ian³,Ariyarajah Archchun³,Carino Marylin³,Massaquoi Thomas²,Broutet Nathalie³,Xu Wenbo¹,Wu Guizhen¹,Ströher Ute⁴,Gao George F¹,Formenty Pierre³,Sahr Foday²,Deen Gibrilla F⁵,Bangura James,Jambai Amara,James Faustine,Wurie Alie,Yamba Francis,Sahr Foday,Fornah Halima,Kamara Richard,Massaquoi Thomas A,Sesay Foday R,Davies Tina,

Affiliation:

1. NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

2. The Sierra Leone Ministry of Defense, Freetown, Sierra Leone

3. World Health Organization, Geneva, Switzerland

4. Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia

5. The Sierra Leone Ministry of Health and Sanitation, Freetown, Sierra Leone

Abstract

Abstract The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.

Funder

World Health Organization

United States Centers for Disease Control and Prevention

Chinese Centers for Disease Control and Prevention

Paul G. Allen Family Foundation

Joint United Nations Program on HIV/AIDS,

Major Special Projects for Infectious Disease Research of China

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/6/3/ofz068/33590408/ofz068.pdf

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