A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry-Reference-Cited by-同舟云学术

A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Tong Liangqin¹²,Wang Lin¹,Liao Shumin³⁴,Xiao Xiaoping¹,Qu Jing⁵,Wu Chunli⁵,Zhu Yibin¹,Tai Wanbo²,Huang Yanhong⁶⁷,Wang Penghua⁸,Li Liang⁶⁷,Zhang Renli⁵,Xiang Ye¹,Cheng Gong¹²^ORCID

Affiliation:

1. Tsinghua-Peking Joint Center for Life Sciences, Beijing Frontier Research Center for Biological Structure and Beijing Advanced Innovation Center for Structural Biology, School of Medicine, Tsinghua University, Beijing, China

2. Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China

3. Department of Otolaryngology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China

4. Department of Thoracic Surgery, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China

5. Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China

6. Department of Pharmacology, School of Medicine, Southern University of Science and Technology, Shenzhen, China

7. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

8. Department of Immunology, School of Medicine, the University of Connecticut Health Center, Farmington, Connecticut, USA

Abstract

Retinoids, a group of compounds including vitamin A and its active metabolite all- trans retinoic acid (ATRA), regulate serial physiological activity in multiple organ systems, such as cell growth, differentiation, and apoptosis. The ATRA analogues reported to date include more than 4,000 natural and synthetic molecules that are structurally and/or functionally related to ATRA.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Tsinghua University Spring Breeze Fund

Shenzhen Science and Technology Project

Shenzhen San-Ming Project for Prevention and Research on Vector-borne Disease

Innovation Team Project of Yunnan Science and Technology Department

Yunnan Cheng gong expert workstation

Science and Technology Planning Project of Guangdong Province of China

Publisher

American Society for Microbiology

Subject