Antibiotic Acyldepsipeptides Stimulate the <i>Streptomyces</i> Clp-ATPase/ClpP Complex for Accelerated Proteolysis-Reference-Cited by-同舟云学术

Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Reinhardt Laura¹²,Thomy Dhana¹²,Lakemeyer Markus³,Westermann Linda Maria¹²,Ortega Joaquin⁴,Sieber Stephan A.³^ORCID,Sass Peter¹²^ORCID,Brötz-Oesterhelt Heike¹²^ORCID

Affiliation:

1. Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

2. Cluster of Excellence–Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany

3. Department of Chemistry, Technical University of Munich, Garching, Germany

4. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada

Abstract

Clp proteases are antibiotic and anticancer drug targets. Composed of the proteolytic core ClpP and a regulatory Clp-ATPase, the protease machinery is important for protein homeostasis and regulatory proteolysis.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01413-22

Reference80 articles.

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3. Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces

4. The Level of AdpA Directly Affects Expression of Developmental Genes in Streptomyces coelicolor

5. Regulation of the clpP1clpP2 operon by the pleiotropic regulator AdpA in Streptomyces lividans

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