Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies-Reference-Cited by-同舟云学术

Capability of 11 Antipneumococcal Antibiotics To Select for Resistance by Multistep and Single-Step Methodologies

Published:2007-11 Issue:11 Volume:51 Page:4196-4201
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Clark Catherine L.¹,Kosowska-Shick Klaudia¹,Ednie Lois M.¹,Appelbaum Peter C.¹

Affiliation:

1. Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Abstract

ABSTRACT Testing of 12 pneumococcal strains with differing resistotypes [including tet (M) positive] showed that tigecycline, amoxicillin-clavulanate, imipenem, and ceftriaxone did not select for resistant clones after 50 sequential subcultures. By comparison, azithromycin, clarithromycin, clindamycin, telithromycin, levofloxacin, moxifloxacin, and gemifloxacin did show resistant clones. Tigecycline also yielded a low frequency of resistance in single-step tests compared to all β-lactams, macrolides/ketolides, and quinolones tested.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00827-07

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