Affiliation:
1. Department of Environmental Toxicology, University of California at Santa Cruz, Santa Cruz, California 95064
Abstract
ABSTRACT
Vibrio cholerae
switches between smooth and rugose colonial variants. The rugose variant produces more vibrio polysaccharides (VPS
El Tor
) and forms well-developed biofilms. Both phenotypes depend on expression of
vps
biosynthesis genes. We identified a positive transcriptional regulator of
vps
gene expression, VpsT, which is homologous to response regulators of two-component regulatory systems. Disruption of
vpsT
in the rugose variant yields smooth colonies, prevents formation of mature biofilms, and decreases
vps
gene expression. The interaction between VpsT and VpsR, a previously identified positive regulator of
vps
genes, was also investigated.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
168 articles.
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