Immunological response to the Brucella abortus GroEL homolog-Reference-Cited by-同舟云学术

Immunological response to the Brucella abortus GroEL homolog

Published:1996-10 Issue:10 Volume:64 Page:4396-4400
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lin J¹,Adams L G¹,Ficht T A¹

Affiliation:

1. Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4467, USA.

Abstract

Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection against a challenge with virulent organisms. The humoral immune response to BaGroEL was restricted to a region of the mature protein which mapped to amino acids 317 to 355 and may represent a useful diagnostic tool for monitoring exposure to B. abortus. Immunity to a challenge with virulent B. abortus S2308 was not observed in the BaGroEL vaccinated mouse model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.64.10.4396-4400.1996

Reference32 articles.

1. Adams L. G. 1990. Development of live Brucella vaccines p. 250-270. In L. G. Adams (ed.) Advances in brucellosis research. Texas A&M University Press College Station.

2. Development of differential diagnostic assays and killed and live vaccines for bovine brucellosis;Adams L. G.;Immunobiology,1989

3. Allen C. S. W. Bearden and T. A. Ficht. 1994. Complement and macrophage mediated killing of transposon derived rough mutants of Brucella American Society for Microbiology 1994. American Society for Microbiology Washington D.C.

4. Temporal development of protective cell-mediated and humoral immunity in Balb/c mice infected with Brucella abortus;Arars L. N.;J. Immunol.,1989

5. Purification and immunological characterization of a GroEL-like protein from Bordetella pertussis;Burns D. L.;Infect. Immun.,1991

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