First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases-Reference-Cited by-同舟云学术

First Report of Klebsiella oxytoca Strain Simultaneously Producing NDM-1, IMP-4, and KPC-2 Carbapenemases

Published:2017-09 Issue:9 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Juan¹²,Yuan Min³,Chen Hai⁴,Chen Xia³,Jia Yuanchun³,Zhu Xiong⁴,Bai Li⁵,Bai Xue¹,Fanning Séamus⁵²⁶,Lu Jinxing³,Li Juan³

Affiliation:

1. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

2. UCD-Centre for Food Safety, School of Public Health, Physiotherapy and Sports Science, University College Dublin, Belfield, Dublin, Ireland

3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China

4. People's Hospital of Sanya, Hainan Province, China

5. Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing, China

6. Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom

Abstract

ABSTRACT The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that bla NDM-1 was carried on an IncX3 plasmid. The bla IMP-4 and bla KPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00877-17

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