Affiliation:
1. Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Abstract
ABSTRACT
Intestinal tuberculosis (TB) continues to be a common disease worldwide. However, the optimal duration of anti-TB medication has not been well established. We therefore compared the efficacy of 6-month and 9-month therapy in the treatment of intestinal TB. Ninety patients definitely diagnosed with intestinal TB were randomized into 6-month (
n
= 45) or 9-month (
n
= 45) treatment groups, prospectively. The primary end point was complete response, defined as endoscopic healing of active lesions. Patients were followed up monthly for 3 months after therapy initiation, then every 3 months until the end of therapy, and finally 1 year later. Relapse was assessed 1 year after the end of therapy by patient interview and colonoscopy. Baseline characteristics were similar in the 6-month and 9-month groups. Intention-to-treat analysis revealed no significant differences between the two groups in complete response (6-month group, 93.3%; 9-month group, 91.1%;
P
= 1.00) or recurrence rate (6-month group, 2.4%; 9-month group, 0.0%;
P
= 1.00). Median follow-up duration was 39 months in the 6-month group and 32 months in the 9-month group. No surgery was performed on any patient in either group. In conclusion, the 6-month therapy was as effective as 9-month therapy in patients with intestinal TB and may have the additional benefits of reduced treatment cost and increased compliance.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference35 articles.
1. Akgun, Y. 2005. Intestinal and peritoneal tuberculosis: changing trends over 10 years and a review of 80 patients. Can. J. Surg.48:131-136.
2. American Thoracic Society. 1992. Control of tuberculosis in the United States. Am. Rev. Respir. Dis.146:1623-1633.
3. Bastani, B., M. R. Shariatzadeh, and F. Dehdashti. 1985. Tuberculous peritonitis—report of 30 cases and review of the literature. Q. J. Med.56:549-557.
4. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America
5. British Thoracic Association. 1982. A controlled trial of six months chemotherapy in pulmonary tuberculosis. Second report: results during the 24 months after the end of chemotherapy. Am. Rev. Respir. Dis.126:460-462.
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