Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli-Reference-Cited by-同舟云学术

Identification of Translocation Inhibitors Targeting the Type III Secretion System of Enteropathogenic Escherichia coli

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mühlen Sabrina¹²³^ORCID,Zapol'skii Viktor A.⁴^ORCID,Bilitewski Ursula³⁵,Dersch Petra¹²³^ORCID

Affiliation:

1. Institute for Infectiology, University of Münster, Münster, Germany

2. Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

3. German Center for Infection Research (DZIF), Partner site HZI Braunschweig and associated site University of Münster, Münster, Germany

4. Institute of Organic Chemistry, Clausthal University of Technology, Clausthal-Zellerfeld, Germany

5. Compound Profiling and Screening, Helmholtz Centre for Infection Research, Braunschweig, Germany

Abstract

Infections with enteropathogenic Escherichia coli (EPEC) cause severe diarrhea in children. The noninvasive bacteria adhere to enterocytes of the small intestine and use a type III secretion system (T3SS) to inject effector proteins into host cells to modify and exploit cellular processes in favor of bacterial survival and replication.

Funder

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00958-21

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