Affiliation:
1. Lilly Research Laboratories, Division of Eli Lilly and Company, Indianapolis, Indiana 46206
Abstract
Ampicillin-resistant and -susceptible strains of
Haemophilus influenzae
were tested for susceptibility to 16 antibiotics. Chloramphenicol and a new cephalosporin, cefamandole, were most active with minimal inhibitory concentrations (MICs) for all bacteria tested between 0.5 to 2.0 μg/ml. All but two organisms were susceptible to tetracycline. Ampicillin-resistant strains of
H. influenzae
were less susceptible (MIC, 4 to 32 μg/ml) to carbenicillin and ticarcillin than ampicillin-susceptible organisms (MIC, 0.25 to 1.0 μg/ml). A rapid assay for β-lactamase, utilizing a chromogenic cephalosporin substrate, detected enzyme production in all 17 ampicillin-resistant strains of
H. influenzae
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference17 articles.
1. Ampicillin-resistant Haemophilus influenzae meningitis;Akomas W. J.;Lancet,1974
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5. Haemophilus influenzae type B resistant to ampicillin. A report of two cases;Khan W.;J. Am. Med. Assoc.,1974
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