Affiliation:
1. Infectious Diseases and Immunology Division, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29401
Abstract
The specific activity, substrate profile, response to inhibitors, inducibility, and cellular localization of the beta-lactamase produced by an ampicillin-resistant strain of
Haemophilus influenzae
type B were investigated. In these properties the enzyme resembles β-lactamases produced by other gram-negative bacilli more closely than those produced by gram-positive organisms. It is quite similar to an enzyme found in strains of
Klebsiella pneumoniae
, and differs significantly from those described in other gram-negative bacilli. Comparison of the substrate profile with the minimal inhibitory concentrations of various β-lactamase antibiotics suggests that the β-lactamase plays an important role in the antibiotic resistance of this organism.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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