Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota-Reference-Cited by-同舟云学术

Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota

Published:2020-01-15 Issue:3 Volume:202 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

O’Sullivan Julie N.¹²³,O’Connor Paula M.¹³,Rea Mary C.¹³,O’Sullivan Orla¹³,Walsh Calum J.¹³,Healy Brian³,Mathur Harsh¹³,Field Des²³,Hill Colin²³,Ross R. Paul¹²³

Affiliation:

1. Teagasc Food Research Centre, Fermoy, County Cork, Ireland

2. School of Microbiology, University College Cork, Cork, Ireland

3. APC Microbiome Ireland, University College Cork, Cork, Ireland

Abstract

This study describes the characterization of nisin J, the first example of a natural nisin variant, produced by a human skin isolate of staphylococcal origin. Nisin J displays inhibitory activity against a wide range of bacterial targets, including MRSA. This work demonstrates the potential of human commensals as a source for novel antimicrobials that could form part of the solution to antibiotic resistance across a broad range of bacterial pathogens.

Funder

Science Foundation Ireland

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00639-19

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